Toxiban Suspension

ToxiBan Suspension with Sorbitol is a convenient, ready-to-use, activated charcoal 
suspension containing 10% activated charcoal, 10% sorbitol and 6.25% kaolin in an 
aqueous base with special suspending agents and preservatives intended for use as an 
emergency treatment of small animals.

Activated charcoal is the most valuable single emergency antidote, since it acts by 
inactivating many organic toxicants by adsorption, a surface-active phenomenon. It is 
considered a universal antidote. Charcoal, with a small particle size, is most effective; 
plant charcoal is more effective than animal charcoal.

Sorbitol is a hexahydric sugar alcohol which primarily serves as an osmotic cathartic. 
It is poorly absorbed during its transit through the gastrointestinal tract. Sorbitol that 
is absorbed is metabolized by the liver and slowly converted to fructose. Insulin is not 
necessary for intracellular transport of sorbitol. Therefore, customary cathartic doses can 
be safely used by animals with diabetes mellitus. As a hyperosmotic cathartic, sorbitol produces a hygroscopic action resulting in increased water in the large intestine and increased intraluminal pressure which stimulates catharsis. Sorbitol does not compromise the adsorptive capacity of activated charcoal.

Activated charcoal given alone becomes stationary in the gastrointestinal tract, releasing its adsorbed toxin which may subsequently be absorbed by the intestinal mucosa to again produce toxicoses. Sorbitol is an effective cathartic for use with activated charcoal in monogastric animals. It promotes passage of the activated charcoal and adsorbed toxin via the feces.

Kaolin is a naturally occurring hydrated aluminum silicate which is powdered and refined for pharmaceutical use. It is not absorbed from the gut after oral administration. Colloidal kaolin is an intestinal protectant for inflamed GI mucosa. Its well-known adsorptive properties in removing bacteria and endotoxins from gastrointestinal contents aid in preventing absorption of these and other GI toxins